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  • HCQ study published in Lancet starting to unravel...

    On its face, it was a major finding: Antimalarial drugs touted by the White House as possible COVID-19 treatments looked to be not just ineffective, but downright deadly. A study published on 22 May in The Lancet used hospital records procured by a little-known data analytics company called Surgisphere to conclude that coronavirus patients taking chloroquine or hydroxychloroquine were more likely to show an irregular heart rhythm—a known side effect thought to be rare—and were more likely to die in the hospital....

    ....the Lancet results have begun to unravel—and Surgisphere, which provided patient data for two other high-profile COVID-19 papers, has come under withering online scrutiny from researchers and amateur sleuths. They have pointed out many red flags in the Lancet paper, including the astonishing number of patients involved and details about their demographics and prescribed dosing that seem implausible. “It began to stretch and stretch and stretch credulity,” says Nicholas White, a malaria researcher at Mahidol University in Bangkok....

    Meanwhile, the questions swirling around the Lancet paper have left leaders of the halted chloroquine trials weighing whether to restart. “The problem is, we are left with all the damage that has been done,” says White, a co-investigator on a trial of hydroxychloroquine for COVID-19 prevention that was halted at the request of U.K. regulators last week. Headlines proclaiming deadly effects will make it hard to recruit patients to key studies, he says. “The whole world thinks now that these drugs are poisonous.”

    ....researchers immediately took issue with the analysis. The study doesn’t properly control for the likelihood that patients getting the experimental drugs were sicker than the controls, says Matthew Semler, a critical care physician at Vanderbilt University. “If you have a physician sitting with two patients who have coronavirus, and the physician chooses to give one of them hydroxychloroquine, they’re doing it for a reason,” he says. The patient may be relying on high levels of supplemental oxygen, for example, or getting worse over time. But those kinds of details aren’t available about the patients in the Lancet study, he notes....

    “This is a drug that has been used for decades. It’s not like we know nothing about its safety,” says Miguel Hernán, a Harvard epidemiologist and co-investigator on an ongoing trial of hydroxychloroquine in Spain and Latin America for COVID-19 prevention in health care workers.

    The controversy has been an unfortunate distraction, Hernán adds. “If you do something as inflammatory as this without a solid foundation, you are going to make a lot of people waste time trying to understand what is going on.”

    Chaccour says both NEJM and The Lancet should have scrutinized the provenance of Surgisphere’s data more closely before publishing the studies. “Here we are in the middle of a pandemic with hundreds of thousands of deaths, and the two most prestigious medical journals have failed us,” he says.

    https://www.sciencemag.org/news/2020...-be-unraveling
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    "Any story sounds true until someone tells the other side and sets the record straight." -Proverbs 18:17

  • #2
    Here's the most recent released study from the New England Journal of Medicine for reference:
    https://www.nejm.org/doi/full/10.105...YeCao0.twitter

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    • #3
      These studies are poorly controlled for obvious reasons.

      It was never thought that the drug prevented infection only that it may improve long term outcome.

      The bottom line is that by now we should have better alternatives. When it was the only game in town it would have been foolish to not try it if your doctor recommended it.

      The problem is doctors routinely recommend drugs such as pain killers that kill people. All drugs regardless of how well researched they are come with unintended consequences. That's life
      We hunt the hunters

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      • #4
        Not quite. People routinely abuse their prescriptions and demand treatments they do not need.
        Quis Custodiet Ipsos Custodes? Who is watching the watchers?

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        • #5
          When my roommate was admitted to the hospital, he was in bad shape. They gave him hydroxychloroquine and his condition improved remarkably. He was able to eat solid food. That was a miracle according to the doctors.

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          • #6
            Originally posted by Mountain Man View Post
            Not quite. People routinely abuse their prescriptions and demand treatments they do not need.
            There you go again arguing with me

            Of course your right that people should be responsible for their own medical care it's one of our greatest freedoms to not be dictated to by a bureaucrat.

            Still I can recall several relatively recent fades that doctors should have known would turn out badly.

            https://www.pbs.org/wgbh/pages/front...d/fenphen.html

            PS sorry about the link to a mockingbird media outlet I will try harder
            We hunt the hunters

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            • #7
              Originally posted by wolfhnd View Post

              There you go again arguing with me

              Of course your right that people should be responsible for their own medical care it's one of our greatest freedoms to not be dictated to by a bureaucrat.

              Still I can recall several relatively recent fades that doctors should have known would turn out badly.

              https://www.pbs.org/wgbh/pages/front...d/fenphen.html

              PS sorry about the link to a mockingbird media outlet I will try harder
              My response was based n my own lengthy experiences with patient demands and non-compliance. We're both right. And America is The Land Of Pills and Potions.
              Quis Custodiet Ipsos Custodes? Who is watching the watchers?

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              • #8
                Retraction by Lancet-
                https://www.thelancet.com/journals/l...324-6/fulltext

                MSM reported on study back in May but ignores retraction-
                https://www.foxnews.com/media/networ...rt-retractions
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                "Any story sounds true until someone tells the other side and sets the record straight." -Proverbs 18:17

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